Growth
Sermorelin GRF 1-29 · GHRH Analogue
Growth
Sermorelin research overview
- CAS Number
- 86168-78-7
- Molecular Formula
- C₁₄₉H₂₄₆N₄₄O₄₂S
- HPLC Purity
- ≥99% (batch-verified)
- Form
- Lyophilised powder
- Storage
- 2–8°C, desiccated, protected from light
- Classification
- Research reagent - in vitro use only
Sermorelin is a synthetic 29-amino-acid peptide corresponding to the first 29 residues of growth hormone-releasing hormone (GHRH). It is the shortest fragment of GHRH that retains full activity at the GHRH receptor, which makes it a long-established reference agonist in growth-axis research.
Native GHRH is a 44-residue hypothalamic peptide. Structure-activity work in the early 1980s showed that the N-terminal 29 residues carry the receptor-binding and activation determinants, and the amidated fragment GRF(1-29)-NH₂ became the standard research form. Its sequence is identical to the corresponding region of human GHRH, with a C-terminal amide.
In cell-based research, Sermorelin is used to study GHRH receptor signalling in pituitary somatotroph models, where receptor activation is coupled through Gαs to adenylyl cyclase and cAMP accumulation. It is used as a positive control in receptor binding and functional assays, and as a comparator when characterising stabilised GHRH analogues.
Sermorelin is closely related to two other compounds in the catalogue: CJC-1295 without DAC (a tetrasubstituted GRF 1-29 analogue with greater resistance to enzymatic cleavage in experimental systems) and Tesamorelin (a full-length GHRH analogue with an N-terminal trans-3-hexenoyl group). Velox Peptides supplies Sermorelin at ≥99% HPLC-verified purity as a 5mg lyophilised research reagent. Not for human or veterinary consumption.
Summary paraphrased from the peer-reviewed preclinical literature. For in vitro research use only. For source citations, email support@veloxpeps.com.
Sermorelin Research Hub
Technical data
Compound specifications
| Common name | Sermorelin (GRF 1-29, GHRH (1-29)) |
|---|---|
| Full name | Growth hormone-releasing hormone (1-29) amide |
| CAS number | 86168-78-7 |
| Molecular formula | C₁₄₉H₂₄₆N₄₄O₄₂S |
| Molecular weight | 3357.9 g/mol |
| Sequence | Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-NH2 |
| HPLC purity | ≥99% (batch-verified) |
| Appearance | White to off-white lyophilised powder |
| Solubility | Bacteriostatic water, sterile saline |
| Storage (lyophilised) | 2–8°C, protected from light |
| Storage (reconstituted) | 2–8°C, up to 28 days |
| Supplied as | 5mg |
Purity & documentation
Batch testing and certificate of analysis
Every batch of Sermorelin is third-party HPLC-tested prior to dispatch. Batch documentation is available on request.
Previous batch CoAs are archived in the CoA library. For batch-specific CoA requests prior to purchase, contact support@veloxpeps.com.
Delivery & payment
Buying Sermorelin in the UK
Sermorelin is sold by Velox Peptides (CRP Labs Ltd, UK company no. NI738125) and dispatched from the UK. Choose a vial size, pay on one page, and your order is dispatched the next working day.
- Delivery: Royal Mail Tracked 24 (1–2 working days, £5.99, free over £100) or Tracked 48 (2–3 working days, £3.80). See shipping.
- Payment: Pay by Bank through FCA-authorised open banking, or bank transfer. No card details needed.
- Testing: See the batch testing details above and past reports in the CoA library.
- Research use only: Supplied as a research reagent for in vitro use. Not for human or veterinary consumption. See our Research Use Policy.
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Compliance notice
For in vitro research use only. Sermorelin is supplied solely as a research reagent for qualified professionals conducting in vitro or animal-model studies. It is not a medicinal product within the meaning of the Human Medicines Regulations 2012. It has not been evaluated by the MHRA or FDA. It is not intended for human or veterinary consumption, diagnosis, treatment, cure, or prevention of any condition. Any use outside lawful scientific research is outside the scope of sale.
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