STACK IMAGETesamorelin Growth Hormone Releasing Factor Analogue
Tesamorelin is a synthetic version of GHRH (Growth Hormone-Releasing Hormone - the signal the brain uses to trigger growth hormone production). Structural modifications have been added to slow how quickly it breaks down in the body, giving it a longer active window. Research has investigated its effects on GH (growth hormone) and IGF-1 (a related signalling protein) levels, and studies have examined its influence on fat distribution around the abdominal area in animal models.
- CAS Number
- 218949-48-5
- Molecular Formula
- C₂₂₁H₃₅₆N₆₄O₆₈S
- HPLC Purity
- ≥99% (batch-verified)
- Form
- Lyophilised powder
- Storage
- 2–8°C, desiccated, protected from light
- Classification
- Research reagent - in vitro use only
Tesamorelin research overview
Tesamorelin is a 44-amino-acid synthetic analogue of full-length endogenous Growth Hormone Releasing Hormone (GHRH(1-44)), modified at the N-terminus with a trans-3-hexenoic acid conjugate to improve metabolic stability relative to native GHRH. Unlike CJC-1295 wo DAC — which corresponds only to the shorter GHRH(1-29) fragment — Tesamorelin encompasses the complete natural GHRH sequence, providing a research tool that more closely approximates the endogenous hormone’s structure. The N-terminal modification extends its half-life in experimental conditions while preserving the primary GHRH receptor binding interaction.
Preclinical and clinical research on Tesamorelin has focused on two principal areas: growth hormone secretagogue biology and visceral adipose tissue metabolism. As a GHRH receptor (GHRHR) agonist, Tesamorelin stimulates GH release from anterior pituitary somatotroph cells. Research examining the metabolic consequences of GH elevation via Tesamorelin has particularly focused on visceral adipose tissue — the metabolically active fat deposited around abdominal organs — with studies examining effects on adipocyte lipolysis, circulating lipid markers (triglycerides, LDL, HDL), and lean mass and adipose tissue distribution parameters in animal models.
Tesamorelin is also studied in the context of downstream IGF-1 (Insulin-like Growth Factor 1) signalling and in neurological research examining whether GHRH receptor agonism affects cognitive and CNS function markers in preclinical models, building on evidence that GH and IGF-1 receptors are expressed in hippocampal tissue. Its full-length GHRH sequence makes it a useful comparator with truncated GHRH analogues in studies examining receptor occupancy, activation kinetics, and downstream signalling profiles. Velox Peptides supplies Tesamorelin at ≥99% HPLC-verified purity as a lyophilised research reagent. Not for human or veterinary consumption.
Summary paraphrased from the peer-reviewed preclinical literature. For in vitro research use only. For source citations, email support@veloxpeps.com.
Compound specifications
| Common name | Tesamorelin |
|---|---|
| Full name | Growth Hormone Releasing Factor Analogue |
| CAS number | 218949-48-5 |
| Molecular formula | C₂₂₁H₃₅₆N₆₄O₆₈S |
| Molecular weight | 5195.8 g/mol |
| Sequence | trans-3-hexenoyl-YADAIFTNSYRKVLGQLSARKLLQDIMSR-NH2 |
| HPLC purity | ≥99% (batch-verified) |
| Appearance | White to off-white lyophilised powder |
| Solubility | Bacteriostatic water, sterile saline |
| Storage (lyophilised) | 2–8°C, protected from light |
| Storage (reconstituted) | 2–8°C, up to 28 days |
| Supplied as | 15mg |
Batch testing and certificate of analysis
Every batch of Tesamorelin is third-party HPLC-tested prior to dispatch. Batch documentation is available on request.
Previous batch CoAs are archived in the CoA library. For batch-specific CoA requests prior to purchase, contact support@veloxpeps.com.
Frequently Asked Research-Use Questions
What purity is Velox Peptides Tesamorelin?
How is Tesamorelin supplied and reconstituted for research use?
What is Tesamorelin used for in preclinical research?
What is the CAS number for Tesamorelin?
Is Tesamorelin legal to buy in the UK?
How does Tesamorelin compare to CJC-1295 wo DAC as a research compound?
How quickly is my order dispatched and delivered?
How do I pay, and is it secure?
Does my order include a certificate of analysis?
Compliance notice
For in vitro research use only. Tesamorelin is supplied solely as a research reagent for qualified professionals conducting in vitro or animal-model studies. It is not a medicinal product within the meaning of the Human Medicines Regulations 2012. It has not been evaluated by the MHRA or FDA. It is not intended for human or veterinary consumption, diagnosis, treatment, cure, or prevention of any condition. Any use outside lawful scientific research is outside the scope of sale.

