STACK IMAGE - RESEARCH BUNDLE · 3 COMPOUNDS
Incretin Receptor Research Bundle
Mots-C + NAD+ + Retatrutide
Mots-C10mg£29.99NAD+1000mg£82.30Retatrutide20mg£109.99
£222.28
£147.98
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- Metabolic
Mots-C Mitochondrial Open Reading Frame Peptide
For in vitro research use only. Mots-C is not for human or veterinary consumption, diagnosis, treatment, or prevention of any condition.
Mots-C is a small peptide (16 amino acids long) with an unusual origin: its instructions are encoded in the DNA found inside mitochondria (the parts of a cell that produce energy), not in the cell's main DNA. Under metabolic stress, studies have investigated how it travels to the cell's nucleus and activates AMPK - an enzyme that acts like a fuel gauge for the cell, sensing how much energy is available and adjusting the cell's behaviour.
- CAS Number
- 1627580-64-6
- Molecular Formula
- C₁₀₁H₁₅₂N₂₈O₂₂S₂
- HPLC Purity
- ≥99% (batch-verified)
- Form
- Lyophilised powder
- Storage
- 2–8°C, desiccated, protected from light
- Classification
- Research reagent - in vitro use only
≥99%
HPLC purity
3rd-Party Tested
Independent lab
CoA Every Order
Batch-specific
Tracked 24
Royal Mail UK
Pay by Bank
No card stored
Mots-C research overview
Mots-C is a 16-amino-acid peptide encoded within the mitochondrial genome — specifically within the 12S ribosomal RNA (rRNA) gene — making it one of the very few biologically active peptides known to be encoded by mitochondrial rather than nuclear DNA. It was first identified in 2015 by researchers examining small open reading frames (sORFs) within the mitochondrial genome. As a mitochondrial-derived peptide (MDP), Mots-C occupies a distinct research category: it is an endogenous signalling molecule that appears to communicate mitochondrial metabolic status to other cellular compartments — a form of retrograde (mitochondria-to-nucleus) signalling.
Preclinical research on Mots-C has primarily focused on metabolic regulation. Cell culture studies have reported that Mots-C activates AMP-activated protein kinase (AMPK), a master sensor of cellular energy status that is activated when the AMP:ATP ratio rises. Downstream of AMPK activation, researchers have examined effects on glucose uptake, fatty acid oxidation, and insulin signalling in skeletal muscle cell lines. Rodent studies have investigated Mots-C administration in diet-induced metabolic dysfunction models, examining changes in lean mass and adipose tissue distribution parameters, glucose tolerance, and insulin sensitivity markers. Research has also examined its effects on the folate cycle and AICAR metabolism, suggesting involvement in purine biosynthesis regulation.
Beyond metabolic biology, Mots-C has attracted research interest in the context of ageing and cellular stress responses. Plasma Mots-C concentrations have been reported to change with age and metabolic status in human samples, prompting investigation of its role as a research marker. Its unique mitochondrial origin and systemic signalling properties make it a subject of growing interest in longevity biology, mitochondrial communication research, and exercise physiology studies. Velox Peptides supplies Mots-C at ≥99% HPLC-verified purity as a lyophilised research reagent. Not for human or veterinary consumption.
Summary paraphrased from the peer-reviewed preclinical literature. For in vitro research use only. For source citations, email support@veloxpeps.com.
📖 MOTS-c Research Hub
Compound specifications
| Common name | Mots-C |
|---|---|
| Full name | Mitochondrial Open Reading Frame Peptide |
| CAS number | 1627580-64-6 |
| Molecular formula | C₁₀₁H₁₅₂N₂₈O₂₂S₂ |
| Molecular weight | 2174.5 g/mol |
| Sequence | MRWQEMGYIFYPRKLR |
| HPLC purity | ≥99% (batch-verified) |
| Appearance | White to off-white lyophilised powder |
| Solubility | Bacteriostatic water, sterile saline |
| Storage (lyophilised) | 2–8°C, protected from light |
| Storage (reconstituted) | 2–8°C, up to 28 days |
| Supplied as | 10mg |
Batch testing and certificate of analysis
Every batch of Mots-C is third-party HPLC-tested prior to dispatch. Batch documentation is available on request.
Previous batch CoAs are archived in the CoA library. For batch-specific CoA requests prior to purchase, contact support@veloxpeps.com.
Stacks containing Mots-C
STACK IMAGERelated compounds
Frequently Asked Research-Use Questions
What purity is Velox Peptides Mots-C?
Mots-C is supplied at ≥99% HPLC-verified purity. Batch documentation is available on request.
How is Mots-C supplied and reconstituted for research use?
Mots-C is supplied as a lyophilised powder in sterile single-use vials. For in vitro research use, reconstitution is performed with bacteriostatic water. See the reconstitution calculator for volume calculations based on required concentration.
What is Mots-C used for in preclinical research?
Mots-C is studied in the peer-reviewed literature across the pathways described in the research overview above. Velox Peptides supplies Mots-C strictly as a research reagent for in vitro use by qualified researchers. It is not a medicinal product and is not for human or veterinary consumption.
Is Mots-C legal to buy in the UK?
Yes. Mots-C is lawful to purchase in the United Kingdom strictly for legitimate in vitro scientific research purposes. It is not a controlled substance under UK law and is not subject to prescription requirements when purchased for research use. Velox Peptides supplies Mots-C solely as a research reagent to qualified researchers. Buyers are responsible for ensuring all use complies with applicable law and with Velox Peptides’ Research Use Policy.
Why is Mots-C considered a mitochondrial-derived peptide (MDP)?
Mots-C is encoded within a small open reading frame (sORF) inside the 12S ribosomal RNA gene of the mitochondrial genome — not the nuclear genome like most proteins. Its classification as a mitochondrial-derived peptide (MDP) reflects this unique origin. Unlike nuclear-encoded proteins that are imported into mitochondria, Mots-C is translated within the mitochondrion and then travels to the nucleus and cytoplasm to exert regulatory effects. This retrograde signalling mechanism — mitochondria communicating metabolic state to the rest of the cell — is a relatively new area of cell biology that Mots-C has helped define.
How quickly is my order dispatched and delivered?
Orders placed before 2pm on a working day are dispatched the same day via Royal Mail Tracked 24, typically arriving in 1–2 working days, with tracking emailed on dispatch. UK shipping is free over £100, and EU shipping is available.
How do I pay, and is it secure?
We accept Pay by Bank - an instant, secure open-banking payment via Fena, where you authorise the payment in your own banking app and no card details are stored on our site. Manual UK bank transfer is available as a fallback. Orders are dispatched within 24 hours of cleared payment.
Does my order include a certificate of analysis?
Yes. Every order includes a batch-specific Certificate of Analysis documenting third-party HPLC purity and mass-spectrometry identity confirmation, emailed with your order confirmation. Previous batch CoAs are archived in our CoA library.
Compliance notice
For in vitro research use only. Mots-C is supplied solely as a research reagent for qualified professionals conducting in vitro or animal-model studies. It is not a medicinal product within the meaning of the Human Medicines Regulations 2012. It has not been evaluated by the MHRA or FDA. It is not intended for human or veterinary consumption, diagnosis, treatment, cure, or prevention of any condition. Any use outside lawful scientific research is outside the scope of sale.
