STACK IMAGECJC-1295 wo DAC Growth Hormone Releasing Factor Analogue (no DAC)
CJC-1295 (without DAC) is a synthetic version of a signal molecule the brain naturally uses to trigger growth hormone release. Without the DAC (Drug Affinity Complex - a chemical attachment that makes some versions last much longer in the body), this compound produces a short, sharp pulse of growth hormone - more like the natural pattern the body uses.
- CAS Number
- 863288-34-0
- Molecular Formula
- C₁₅₂H₂₅₂N₄₄O₄₂
- HPLC Purity
- 99.1% (batch-verified)
- Form
- Lyophilised powder
- Storage
- 2–8°C, desiccated, protected from light
- Classification
- Research reagent - in vitro use only
CJC-1295 wo DAC research overview
CJC-1295 without DAC (wo DAC) is a 30-amino-acid synthetic analogue of Growth Hormone Releasing Hormone 1-29 (GHRH(1-29)) — the minimally active N-terminal fragment of endogenous GHRH responsible for receptor binding and GH secretion. It incorporates several amino acid substitutions compared to native GHRH(1-29) (sermorelin) that improve its enzymatic stability and receptor binding affinity. The designation “without DAC” (without Drug Affinity Complex) indicates the absence of a maleimidoproprionic acid (MPA) moiety that would otherwise allow covalent binding to circulating albumin for extended half-life — making CJC-1295 wo DAC a shorter-acting GHRH analogue compared to the DAC formulation.
Research on CJC-1295 wo DAC centres on growth hormone secretagogue biology — the study of compounds that stimulate growth hormone (GH) release from the anterior pituitary via the GHRH receptor (GHRHR). In preclinical animal models, GHRH analogues have been examined for their ability to stimulate pulsatile GH secretion and to examine the downstream effects on circulating IGF-1 (Insulin-like Growth Factor 1), which mediates many of GH’s anabolic and metabolic effects in peripheral tissues. The shorter half-life of CJC-1295 wo DAC makes it useful for studies requiring acute, defined GH stimulation windows rather than prolonged elevation.
As a research tool, CJC-1295 wo DAC is frequently used in studies examining GHRH receptor pharmacology, GH secretion dynamics, and pituitary function in rodent models. It is also studied alongside GHRP (growth hormone releasing peptide) compounds in combinatorial protocols, as GHRH receptor agonists and ghrelin receptor agonists act synergistically on somatotroph cells to amplify GH release. Velox Peptides supplies CJC-1295 wo DAC at 99.1% HPLC-verified purity as a lyophilised research reagent for in vitro use. Not for human or veterinary consumption.
Summary paraphrased from the peer-reviewed preclinical literature. For in vitro research use only. For source citations, email support@veloxpeps.com.
Compound specifications
| Common name | CJC-1295 wo DAC |
|---|---|
| Full name | Growth Hormone Releasing Factor Analogue (no DAC) |
| CAS number | 863288-34-0 |
| Molecular formula | C₁₅₂H₂₅₂N₄₄O₄₂ |
| Molecular weight | 3367.8 g/mol |
| Sequence | HAIBU-Y-D-Ala-DFA-LRKVLGQLSARKLLQDIMSR-NH2 (no DAC) |
| HPLC purity | 99.1% (batch-verified) |
| Appearance | White to off-white lyophilised powder |
| Solubility | Bacteriostatic water, sterile saline |
| Storage (lyophilised) | 2–8°C, protected from light |
| Storage (reconstituted) | 2–8°C, up to 28 days |
| Supplied as | 10mg |
Batch testing and certificate of analysis
Every batch of CJC-1295 wo DAC is third-party HPLC-tested prior to dispatch. Batch documentation is available on request.
Previous batch CoAs are archived in the CoA library. For batch-specific CoA requests prior to purchase, contact support@veloxpeps.com.
Frequently Asked Research-Use Questions
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Compliance notice
For in vitro research use only. CJC-1295 wo DAC is supplied solely as a research reagent for qualified professionals conducting in vitro or animal-model studies. It is not a medicinal product within the meaning of the Human Medicines Regulations 2012. It has not been evaluated by the MHRA or FDA. It is not intended for human or veterinary consumption, diagnosis, treatment, cure, or prevention of any condition. Any use outside lawful scientific research is outside the scope of sale.
