Buy KPV UK – research peptide, HPLC-verified ≥99% purity KPV PRODUCT IMAGE
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KPV Lys-Pro-Val Tripeptide

For in vitro research use only. KPV is not for human or veterinary consumption, diagnosis, treatment, or prevention of any condition.

KPV is a naturally occurring tripeptide consisting of the amino acids lysine, proline, and valine. It corresponds to the C-terminal sequence of alpha-melanocyte-stimulating hormone (α-MSH). Preclinical studies have investigated how KPV interacts with inflammatory signalling pathways, particularly NF-κB-mediated cytokine expression, and its potential role in tissue-repair and mucosal repair models.

CAS Number
13147-97-2
Molecular Formula
C₁₄H₂₅N₃O₄
HPLC Purity
≥99% (batch-verified)
Form
Lyophilised powder
Storage
2–8°C, desiccated, protected from light
Classification
Research reagent - in vitro use only
≥99%
HPLC purity
3rd-Party Tested
Independent lab
CoA Every Order
Batch-specific
Tracked 24
Royal Mail UK
Pay by Bank
No card stored

KPV research overview

KPV is a tripeptide consisting of the amino acids lysine, proline, and valine (Lys-Pro-Val), representing the C-terminal tripeptide fragment of alpha-melanocyte-stimulating hormone (α-MSH). Alpha-MSH is a 13-amino-acid endogenous neuropeptide involved in pigmentation, inflammation, and energy regulation, derived from pro-opiomelanocortin (POMC). KPV was identified as the minimum active sequence of α-MSH required to retain anti-inflammatory activity in certain preclinical models, offering a smaller and more tractable research tool than the full 13-residue α-MSH while targeting overlapping biological pathways.

Preclinical research on KPV has focused primarily on inflammatory signalling in cell culture and rodent models. Studies have examined its effects on pro-inflammatory cytokine production — particularly IL-1β, TNF-α, and IL-6 — in stimulated macrophage and monocyte cell lines, with researchers investigating its interaction with NF-κB signalling pathways associated with inflammatory gene transcription. Research in gastrointestinal biology has investigated KPV’s effects in colitis models and intestinal epithelial cell culture, examining its interaction with gut epithelial tight junction function and mucosal immune responses.

In dermatological and skin biology research, KPV has been studied in models of skin inflammation and tissue repair mechanisms, with cell studies examining its effects on keratinocyte cytokine production and dermal fibroblast activity. KPV is thought to act at least partly through melanocortin receptor interaction — MC1R and MC3R binding studies have been reported — though its mechanism in gut epithelial models may involve additional receptor-independent pathways. Its small tripeptide size gives it potentially favourable cell permeability characteristics in experimental settings. Velox Peptides supplies KPV at ≥99% HPLC-verified purity as a lyophilised research reagent. Not for human or veterinary consumption.

Summary paraphrased from the peer-reviewed preclinical literature. For in vitro research use only. For source citations, email support@veloxpeps.com.

📖  KPV Research Hub
KPV Research Overview Reconstitution Guide

Compound specifications

Common nameKPV
Full nameLys-Pro-Val Tripeptide
CAS number13147-97-2
Molecular formulaC₁₄H₂₅N₃O₄
Molecular weight299.4 g/mol
SequenceLys-Pro-Val
HPLC purity≥99% (batch-verified)
AppearanceWhite to off-white lyophilised powder
SolubilityBacteriostatic water, sterile saline
Storage (lyophilised)2–8°C, protected from light
Storage (reconstituted)2–8°C, up to 28 days
Supplied as10mg

Batch testing and certificate of analysis

Every batch of KPV is third-party HPLC-tested prior to dispatch. Batch documentation is available on request.

Previous batch CoAs are archived in the CoA library. For batch-specific CoA requests prior to purchase, contact support@veloxpeps.com.

Frequently Asked Research-Use Questions

What purity is Velox Peptides KPV?
KPV is supplied at ≥99% HPLC-verified purity. Batch documentation is available on request.
How is KPV supplied and reconstituted for research use?
KPV is supplied as a lyophilised powder in sterile single-use vials. For in vitro research use, reconstitution is performed with bacteriostatic water. See the reconstitution calculator for volume calculations based on required concentration.
What is KPV used for in preclinical research?
KPV is studied in the peer-reviewed literature across the pathways described in the research overview above. Velox Peptides supplies KPV strictly as a research reagent for in vitro use by qualified researchers. It is not a medicinal product and is not for human or veterinary consumption.
What is the CAS number for KPV?
The CAS registry number for KPV is 13147-97-2.
Is KPV legal to buy in the UK?
Yes. KPV is lawful to purchase in the United Kingdom strictly for legitimate in vitro scientific research purposes. It is not a controlled substance under UK law and is not subject to prescription requirements when purchased for research use. Velox Peptides supplies KPV solely as a research reagent to qualified researchers. Buyers are responsible for ensuring all use complies with applicable law and with Velox Peptides’ Research Use Policy.
What is the structural relationship between KPV and alpha-MSH?
KPV (Lys-Pro-Val) is the C-terminal tripeptide fragment of alpha-melanocyte-stimulating hormone (α-MSH, sequence: Ac-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH₂). The full α-MSH sequence contains 13 amino acids; KPV comprises positions 11–13. Research has identified KPV as the minimum active sequence for anti-inflammatory activity in certain experimental models, suggesting the C-terminal region is important for this activity. This makes KPV a useful pharmacological tool for studying the anti-inflammatory mechanisms of the melanocortin system with a simpler, more defined compound than the full α-MSH peptide.
How quickly is my order dispatched and delivered?
Orders placed before 2pm on a working day are dispatched the same day via Royal Mail Tracked 24, typically arriving in 1–2 working days, with tracking emailed on dispatch. UK shipping is free over £100, and EU shipping is available.
How do I pay, and is it secure?
We accept Pay by Bank - an instant, secure open-banking payment via Fena, where you authorise the payment in your own banking app and no card details are stored on our site. Manual UK bank transfer is available as a fallback. Orders are dispatched within 24 hours of cleared payment.
Does my order include a certificate of analysis?
Yes. Every order includes a batch-specific Certificate of Analysis documenting third-party HPLC purity and mass-spectrometry identity confirmation, emailed with your order confirmation. Previous batch CoAs are archived in our CoA library.

For in vitro research use only. KPV is supplied solely as a research reagent for qualified professionals conducting in vitro or animal-model studies. It is not a medicinal product within the meaning of the Human Medicines Regulations 2012. It has not been evaluated by the MHRA or FDA. It is not intended for human or veterinary consumption, diagnosis, treatment, cure, or prevention of any condition. Any use outside lawful scientific research is outside the scope of sale.

Compliance statement. Velox Peptides supplies research reagents for in vitro use by qualified researchers. Every compound is sold strictly as a research reagent. No product is a medicinal product within the meaning of the Human Medicines Regulations 2012. No product has been evaluated by the MHRA or FDA. No product is intended for human or veterinary consumption, diagnosis, treatment, cure, or prevention of any condition. Any use outside lawful scientific research is outside the scope of sale. See our Research Use Policy and MHRA Statement.