NAD+ Nicotinamide Adenine Dinucleotide

NAD+ (Nicotinamide Adenine Dinucleotide) is a molecule found in every living cell. It plays a central role in how cells produce energy inside mitochondria (the cell's power stations). It is also essential for activating sirtuins - a family of proteins involved in repairing DNA, regulating genes, and helping cells respond to stress.

NAD+ (Nicotinamide Adenine Dinucleotide, oxidised form) is a dinucleotide coenzyme found in all living cells, where it plays a central role in cellular energy metabolism and redox biochemistry. Structurally, NAD+ consists of two nucleotides — one containing adenine and one containing nicotinamide — linked by a phosphate bridge. It cycles between its oxidised form (NAD+) and its reduced form (NADH) as it shuttles electrons in metabolic reactions, acting as an essential electron carrier in glycolysis, the citric acid cycle, and oxidative phosphorylation. Unlike the synthetic peptides in the Velox Peptides catalogue, NAD+ is an endogenous molecule present in every cell of the body.

Beyond its role in bioenergetics, NAD+ is a substrate for several enzymatic reactions that are active subjects of current research. Sirtuins (SIRT1–7), a family of NAD+-dependent protein deacylases, use NAD+ as a cofactor to remove acetyl and acyl groups from target proteins — a regulatory mechanism involved in gene expression, DNA repair, and metabolic enzyme activity. PARP enzymes (poly ADP-ribose polymerases) consume NAD+ to synthesise poly-ADP-ribose chains in response to DNA strand breaks, making NAD+ a central factor in the DNA damage response. CD38 and CD157 use NAD+ to generate cyclic ADP-ribose, a second messenger involved in calcium signalling and immune cell function.

NAD+ levels are reported to decline with age in mammalian tissues, and this decline has prompted research interest in NAD+ biology in the context of aging, mitochondrial dysfunction, neurodegeneration, and metabolic disease. Preclinical cell studies have examined the effects of NAD+ on sirtuin activity, mitochondrial biogenesis markers (including PGC-1α), and the cellular response to oxidative and genotoxic stress. Velox Peptides supplies NAD+ at 99.5% HPLC-verified purity in 1000mg vials as a lyophilised research reagent. Not for human or veterinary consumption.

Summary paraphrased from the peer-reviewed preclinical literature. For in vitro research use only. For source citations, email support@veloxpeps.com.

Every batch of NAD+ is third-party HPLC-tested prior to dispatch. Batch documentation is available on request.

Previous batch CoAs are archived in the CoA library. For batch-specific CoA requests prior to purchase, contact support@veloxpeps.com.

NAD+ is sold by Velox Peptides (CRP Labs Ltd, UK company no. NI738125) and dispatched from the UK. Choose a vial size, pay on one page, and your order is dispatched the next working day.

• Delivery: Royal Mail Tracked 24 (1–2 working days, £5.99, free over £100) or Tracked 48 (2–3 working days, £3.80). See shipping.
• Payment: Pay by Bank through FCA-authorised open banking, or bank transfer. No card details needed.
• Testing: See the batch testing details above and past reports in the CoA library.
• Research use only: Supplied as a research reagent for in vitro use. Not for human or veterinary consumption. See our Research Use Policy.