DSIP Delta Sleep-Inducing Peptide

DSIP is a short neuropeptide (a type of small protein used for signalling between brain cells) made up of just 9 amino acids. It was first isolated from rabbit blood during deep sleep. Animal studies have investigated how it interacts with the structure of sleep - particularly the deep, slow-wave stages - and how it affects the body's stress-response systems.

DSIP (Delta Sleep-Inducing Peptide) is a nonapeptide with the sequence Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu. It was first isolated from the cerebral venous blood of rabbits in 1977 by Schoenenberger and Monnier, following electrical stimulation of the thalamus during sleep induction experiments — giving rise to its name. Unlike most synthetic peptide research compounds, DSIP is an endogenous neuropeptide identified in the hypothalamus, limbic system, pituitary, and peripheral tissues of mammals, though it is supplied here as a synthesised research reagent for controlled experimental conditions.

The primary area of research interest for DSIP has been sleep regulation and neuroendocrine modulation. Early rodent studies reported that peripheral and central administration of DSIP modified slow-wave and delta sleep patterns, though subsequent research has produced variable results and the precise mechanism by which DSIP interacts with sleep architecture remains an active area of investigation. Separately, research has examined DSIP’s role in stress axis modulation — specifically its effects on corticotropin-releasing hormone (CRH) and ACTH secretion — suggesting a potential interface between the sleep regulatory system and the hypothalamic-pituitary-adrenal (HPA) axis.

DSIP has also been studied for antioxidant properties and neuroprotective potential in cell culture models, and for its interaction with opioid peptide systems and basal ganglia function. Its relatively small, stable nonapeptide structure makes it a practical tool for studying receptor binding kinetics and neuroendocrine signalling in vitro. Velox Peptides supplies DSIP at ≥99% HPLC-verified purity as a lyophilised research reagent for in vitro use by qualified researchers. Not for human or veterinary consumption.

Summary paraphrased from the peer-reviewed preclinical literature. For in vitro research use only. For source citations, email support@veloxpeps.com.

Every batch of DSIP is third-party HPLC-tested prior to dispatch. Batch documentation is available on request.

Previous batch CoAs are archived in the CoA library. For batch-specific CoA requests prior to purchase, contact support@veloxpeps.com.

DSIP comes as a 10mg lyophilised vial from £27, or a lab pack of 10 vials at a lower price per vial. Reconstitution uses bacteriostatic water, sold separately, and the reconstitution calculator works out the volumes. For background, read the DSIP research overview, or compare it in Selank vs DSIP.

DSIP is sold by Velox Peptides (CRP Labs Ltd, UK company no. NI738125) and dispatched from the UK. Choose a vial size, pay on one page, and your order is dispatched the next working day.

• Delivery: Royal Mail Tracked 24 (1–2 working days, £5.99, free over £100) or Tracked 48 (2–3 working days, £3.80). See shipping.
• Payment: Pay by Bank through FCA-authorised open banking, or bank transfer. No card details needed.
• Testing: See the batch testing details above and past reports in the CoA library.
• Research use only: Supplied as a research reagent for in vitro use. Not for human or veterinary consumption. See our Research Use Policy.