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Cognitive
Semax ACTH(4-7) Pro-Gly-Pro Analogue
For in vitro research use only. Semax is not for human or veterinary consumption, diagnosis, treatment, or prevention of any condition.
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≥99% PURITY
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≥99%HPLC purity
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Cognitive
Semax research overview
- CAS Number
- 80714-61-0
- Molecular Formula
- C₃₇H₅₁N₉O₁₀S
- HPLC Purity
- 99% (batch-verified)
- Form
- Lyophilised powder
- Storage
- 2–8°C, desiccated, protected from light
- Classification
- Research reagent - in vitro use only
Semax is a synthetic peptide made up of 7 amino acids, based on a fragment of ACTH (Adrenocorticotropic Hormone - a naturally occurring stress hormone). A short chemical tail has been added to make it more stable and longer-lasting inside biological systems. Preclinical studies have investigated its effects on BDNF (Brain-Derived Neurotrophic Factor - a protein that supports brain cell growth and survival) levels in neuronal tissue.
Semax is a synthetic heptapeptide derived from the ACTH(4-7) fragment of adrenocorticotropic hormone (the tetrapeptide Met-Glu-His-Phe), extended at the C-terminus with a Pro-Gly-Pro tripeptide to form the sequence ACTH(4-7)PGP. The Pro-Gly-Pro extension increases resistance to enzymatic degradation, improving the compound’s stability in experimental conditions. Importantly, Semax does not retain the steroidogenic activity of full ACTH — it does not stimulate cortisol production — and research has instead focused on its neurotrophic and neuroprotective properties in animal and cell culture models.
Preclinical research on Semax has concentrated on neuroprotection and cognition models. Studies in rodent models of cerebral ischaemia and oxidative stress have examined whether Semax modifies markers of neuronal damage and survival. Cell culture research has examined its effects on BDNF (brain-derived neurotrophic factor) production — BDNF is a key regulatory protein involved in neuron growth, maintenance, and synaptic plasticity. Studies have reported that Semax upregulates BDNF mRNA expression in hippocampal cell models, making it relevant to neurogenesis and synaptic plasticity research.
Semax has also been studied in the context of monoaminergic systems in rodent models, with researchers examining its influence on serotonin and dopamine activity in brain regions associated with cognition and mood. Its structural similarity to neuropeptides derived from ACTH places it within a broader research programme examining the neuropeptide-cognition interface. Velox Peptides supplies Semax at 99% HPLC-verified purity as a lyophilised research reagent for in vitro use. Not for human or veterinary consumption.
Summary paraphrased from the peer-reviewed preclinical literature. For in vitro research use only. For source citations, email support@veloxpeps.com.
Technical data
Compound specifications
| Common name | Semax |
|---|---|
| Full name | ACTH(4-7) Pro-Gly-Pro Analogue |
| CAS number | 80714-61-0 |
| Molecular formula | C₃₇H₅₁N₉O₁₀S |
| Molecular weight | 813.9 g/mol |
| Sequence | MEHFPGP |
| HPLC purity | 99% (batch-verified) |
| Appearance | White to off-white lyophilised powder |
| Solubility | Bacteriostatic water, sterile saline |
| Storage (lyophilised) | 2–8°C, protected from light |
| Storage (reconstituted) | 2–8°C, up to 28 days |
| Supplied as | 10mg |
Purity & documentation
Batch testing and certificate of analysis
Every batch of Semax is third-party HPLC-tested prior to dispatch. Batch documentation is available on request.
Previous batch CoAs are archived in the CoA library. For batch-specific CoA requests prior to purchase, contact support@veloxpeps.com.
Delivery & payment
Buying Semax in the UK
Semax is sold by Velox Peptides (CRP Labs Ltd, UK company no. NI738125) and dispatched from the UK. Choose a vial size, pay on one page, and your order is dispatched the next working day.
- Delivery: Royal Mail Tracked 24 (1–2 working days, £5.99, free over £100) or Tracked 48 (2–3 working days, £3.80). See shipping.
- Payment: Pay by Bank through FCA-authorised open banking, or bank transfer. No card details needed.
- Testing: See the batch testing details above and past reports in the CoA library.
- Research use only: Supplied as a research reagent for in vitro use. Not for human or veterinary consumption. See our Research Use Policy.
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What purity is Velox Peptides Semax?
Semax is supplied at 99% HPLC-verified purity. Batch documentation is available on request.
How is Semax supplied and reconstituted for research use?
Semax is supplied as a lyophilised powder in sterile single-use vials. For in vitro research use, reconstitution is performed with bacteriostatic water. See the reconstitution calculator for volume calculations based on required concentration.
What is Semax used for in preclinical research?
Semax is studied in the peer-reviewed literature across the pathways described in the research overview above. Velox Peptides supplies Semax strictly as a research reagent for in vitro use by qualified researchers. It is not a medicinal product and is not for human or veterinary consumption.
What is the CAS number for Semax?
The CAS registry number for Semax is 80714-61-0.
Is Semax legal to buy in the UK?
Yes. Research peptides including Semax are lawful to purchase in the United Kingdom strictly for legitimate in vitro scientific research purposes. They are not controlled substances under UK law and are not subject to prescription requirements when purchased for research use. Velox Peptides supplies Semax solely as a research reagent to qualified researchers. Buyers are responsible for ensuring all use complies with applicable law and with Velox Peptides’ Research Use Policy.
What is the relationship between Semax and ACTH in research?
Semax is derived from the ACTH(4-7) fragment (Met-Glu-His-Phe) of adrenocorticotropic hormone, extended with a Pro-Gly-Pro tripeptide. Full ACTH stimulates adrenal cortisol production via the MC2R receptor; Semax does not share this activity and does not bind MC2R. Research interest in Semax is focused on its distinct neurotrophic and neuroprotective properties — particularly BDNF modulation — rather than the hormonal functions associated with the full ACTH peptide. This makes Semax a useful tool for studying ACTH fragment neurobiology without the confound of HPA axis activation.
How quickly is my order dispatched and delivered?
Orders are dispatched the next working day via Royal Mail Tracked 24, typically arriving in 1–2 working days, with tracking emailed on dispatch. UK shipping is free over £100, and EU shipping is available.
How do I pay, and is it secure?
We accept Pay by Bank - an instant, secure open-banking payment via Fena, where you authorise the payment in your own banking app and no card details are stored on our site. Manual UK bank transfer is available as a fallback. Orders are dispatched the next working day after payment clears.
Does my order include a certificate of analysis?
Yes. Every order includes a batch-specific Certificate of Analysis documenting third-party HPLC purity and mass-spectrometry identity confirmation, emailed with your order confirmation. Previous batch CoAs are archived in our CoA library.
Compliance notice
For in vitro research use only. Semax is supplied solely as a research reagent for qualified professionals conducting in vitro or animal-model studies. It is not a medicinal product within the meaning of the Human Medicines Regulations 2012. It has not been evaluated by the MHRA or FDA. It is not intended for human or veterinary consumption, diagnosis, treatment, cure, or prevention of any condition. Any use outside lawful scientific research is outside the scope of sale.
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