Ipamorelin Selective Growth Hormone Secretagogue
Ipamorelin is a synthetic five-amino-acid peptide (a pentapeptide) that selectively switches on the ghrelin receptor - one of the body's signals for releasing growth hormone. In research it is valued as one of the most selective growth hormone secretagogues: it prompts GH release while having little effect on other hormones such as cortisol or prolactin, giving researchers a clean tool for studying this pathway.
- CAS Number
- 170851-70-4
- Molecular Formula
- C₃₈H₄₉N₉O₅
- HPLC Purity
- ≥99% (batch-verified)
- Form
- Lyophilised powder
- Storage
- 2–8°C, desiccated, protected from light
- Classification
- Research reagent - in vitro use only
Research overview
Ipamorelin is a synthetic pentapeptide (Aib-His-D-2-Nal-D-Phe-Lys-NH₂) classified as a growth hormone secretagogue (GHS) and a growth hormone releasing peptide (GHRP). It acts as a selective agonist at the ghrelin receptor (growth hormone secretagogue receptor type 1a, GHS-R1a), the same receptor targeted by the endogenous hormone ghrelin, to stimulate the release of growth hormone (GH) from the anterior pituitary in preclinical models.
What distinguishes Ipamorelin in the research literature is its selectivity. Earlier GHRP compounds such as GHRP-2 and GHRP-6 stimulate GH release but also elevate other pituitary hormones — notably cortisol, prolactin and ACTH. In animal-model studies, Ipamorelin produces GH release with minimal effect on these other axes, making it a useful tool for isolating growth-hormone-secretagogue signalling without confounding hormonal effects. This receptor selectivity is the principal reason it is so widely used as a research reagent.
In growth-hormone-secretagogue research, Ipamorelin is frequently studied alongside GHRH-receptor agonists such as CJC-1295: the ghrelin-receptor and GHRH-receptor pathways act on distinct mechanisms in pituitary somatotroph cells and can amplify GH release synergistically, making the combination a common subject of study. Velox Peptides supplies Ipamorelin at ≥99% HPLC-verified purity as a lyophilised research reagent with batch certificate of analysis. Not for human or veterinary consumption.
Summary paraphrased from the peer-reviewed preclinical literature. For in vitro research use only. For source citations, email support@veloxpeps.com.
Compound specifications
| Common name | Ipamorelin |
|---|---|
| Full name | Selective Growth Hormone Secretagogue (Pentapeptide) |
| CAS number | 170851-70-4 |
| Molecular formula | C₃₈H₄₉N₉O₅ |
| Molecular weight | 711.85 g/mol |
| Sequence | Aib-His-D-2-Nal-D-Phe-Lys-NH₂ |
| HPLC purity | ≥99% (batch-verified) |
| Appearance | White to off-white lyophilised powder |
| Solubility | Bacteriostatic water, sterile saline |
| Storage (lyophilised) | 2–8°C, protected from light |
| Storage (reconstituted) | 2–8°C, up to 28 days |
| Supplied as | 10mg |
Batch testing and certificate of analysis
Every batch of Ipamorelin is third-party HPLC-tested prior to dispatch. Batch documentation is available on request.
Previous batch CoAs are archived in the CoA library. For batch-specific CoA requests prior to purchase, contact support@veloxpeps.com.
Frequently Asked Research-Use Questions
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Compliance notice
For in vitro research use only. Ipamorelin is supplied solely as a research reagent for qualified professionals conducting in vitro or animal-model studies. It is not a medicinal product within the meaning of the Human Medicines Regulations 2012. It has not been evaluated by the MHRA or FDA. It is not intended for human or veterinary consumption, diagnosis, treatment, cure, or prevention of any condition. Any use outside lawful scientific research is outside the scope of sale.
