Melanocortin
PT-141 Bremelanotide · Melanocortin Agonist
Melanocortin
PT-141 research overview
- CAS Number
- 189691-06-3
- Molecular Formula
- C₅₀H₆₈N₁₄O₁₀
- HPLC Purity
- ≥99% (batch-verified)
- Form
- Lyophilised powder
- Storage
- 2–8°C, desiccated, protected from light
- Classification
- Research reagent - in vitro use only
PT-141 (bremelanotide) is a synthetic cyclic heptapeptide agonist of the melanocortin receptor family. It shares the cyclic lactam core of Melanotan II and is used in preclinical research as a reference ligand for central melanocortin receptors, particularly MC3R and MC4R.
PT-141 was identified during work on Melanotan II. Its sequence, Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-OH, is the same cyclic lactam heptapeptide with a free C-terminal carboxylic acid in place of the amide. The His-D-Phe-Arg-Trp pharmacophore common to melanocortin ligands is retained.
In cell-based research, PT-141 is used in receptor binding and cAMP functional assays on cell lines expressing individual melanocortin receptor subtypes, where it behaves as a non-selective agonist with activity at MC1R, MC3R, MC4R and MC5R. Rodent studies have used it as a pharmacological tool to investigate hypothalamic MC4R signalling, often alongside receptor-selective antagonists.
PT-141 sits alongside Melanotan II in the catalogue as a melanocortin reference compound, and the two are frequently compared in receptor pharmacology work. Velox Peptides supplies PT-141 at ≥99% HPLC-verified purity as a 10mg lyophilised research reagent. Not for human or veterinary consumption.
Summary paraphrased from the peer-reviewed preclinical literature. For in vitro research use only. For source citations, email support@veloxpeps.com.
PT-141 Research Hub
Technical data
Compound specifications
| Common name | PT-141 (Bremelanotide, PT141) |
|---|---|
| Full name | Bremelanotide (Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-OH) |
| CAS number | 189691-06-3 |
| Molecular formula | C₅₀H₆₈N₁₄O₁₀ |
| Molecular weight | 1025.2 g/mol |
| Sequence | Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-OH |
| HPLC purity | ≥99% (batch-verified) |
| Appearance | White to off-white lyophilised powder |
| Solubility | Bacteriostatic water, sterile saline |
| Storage (lyophilised) | 2–8°C, protected from light |
| Storage (reconstituted) | 2–8°C, up to 28 days |
| Supplied as | 10mg |
Purity & documentation
Batch testing and certificate of analysis
Every batch of PT-141 is third-party HPLC-tested prior to dispatch. Batch documentation is available on request.
Previous batch CoAs are archived in the CoA library. For batch-specific CoA requests prior to purchase, contact support@veloxpeps.com.
Delivery & payment
Buying PT-141 in the UK
PT-141 is sold by Velox Peptides (CRP Labs Ltd, UK company no. NI738125) and dispatched from the UK. Choose a vial size, pay on one page, and your order is dispatched the next working day.
- Delivery: Royal Mail Tracked 24 (1–2 working days, £5.99, free over £100) or Tracked 48 (2–3 working days, £3.80). See shipping.
- Payment: Pay by Bank through FCA-authorised open banking, or bank transfer. No card details needed.
- Testing: See the batch testing details above and past reports in the CoA library.
- Research use only: Supplied as a research reagent for in vitro use. Not for human or veterinary consumption. See our Research Use Policy.
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Compliance notice
For in vitro research use only. PT-141 is supplied solely as a research reagent for qualified professionals conducting in vitro or animal-model studies. It is not a medicinal product within the meaning of the Human Medicines Regulations 2012. It has not been evaluated by the MHRA or FDA. It is not intended for human or veterinary consumption, diagnosis, treatment, cure, or prevention of any condition. Any use outside lawful scientific research is outside the scope of sale.
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