Neuroendocrine
Kisspeptin-10 Metastin 45-54 · KISS1R Agonist
Neuroendocrine
Kisspeptin-10 research overview
- CAS Number
- 374675-21-5
- Molecular Formula
- C₆₃H₈₃N₁₇O₁₄
- HPLC Purity
- ≥99% (batch-verified)
- Form
- Lyophilised powder
- Storage
- 2–8°C, desiccated, protected from light
- Classification
- Research reagent - in vitro use only
Kisspeptin-10 is the C-terminal decapeptide of the kisspeptin family, encoded by the KISS1 gene. It is the shortest kisspeptin fragment that retains full binding and activity at the KISS1 receptor (KISS1R, also known as GPR54), and it is the standard short ligand used to study this receptor in vitro.
The KISS1 gene product is processed into several peptides (kisspeptin-54, -14, -13 and -10) that share a common C-terminal sequence ending in an Arg-Phe-amide motif. Kisspeptin-54 was first described as metastin, and Kisspeptin-10 corresponds to its residues 45-54. The amidated C-terminus is required for receptor activity.
In cell-based research, Kisspeptin-10 is used in receptor binding assays and in functional assays of KISS1R, a Gq/11-coupled receptor whose activation drives phospholipase C signalling and intracellular calcium mobilisation. It is used to study receptor desensitisation and as a reference agonist when characterising KISS1R antagonists.
In rodent and other animal models, Kisspeptin-10 is a central tool in neuroendocrine research on hypothalamic kisspeptin neurons and their regulation of GnRH neuron activity. Velox Peptides supplies Kisspeptin-10 at ≥99% HPLC-verified purity as a 10mg lyophilised research reagent. Not for human or veterinary consumption.
Summary paraphrased from the peer-reviewed preclinical literature. For in vitro research use only. For source citations, email support@veloxpeps.com.
Kisspeptin-10 Research Hub
Technical data
Compound specifications
| Common name | Kisspeptin-10 (Metastin 45-54, Kisspeptin 10) |
|---|---|
| Full name | Kisspeptin-10 (metastin 45-54) amide |
| CAS number | 374675-21-5 |
| Molecular formula | C₆₃H₈₃N₁₇O₁₄ |
| Molecular weight | 1302.4 g/mol |
| Sequence | Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH2 |
| HPLC purity | ≥99% (batch-verified) |
| Appearance | White to off-white lyophilised powder |
| Solubility | Bacteriostatic water, sterile saline |
| Storage (lyophilised) | 2–8°C, protected from light |
| Storage (reconstituted) | 2–8°C, up to 28 days |
| Supplied as | 10mg |
Purity & documentation
Batch testing and certificate of analysis
Every batch of Kisspeptin-10 is third-party HPLC-tested prior to dispatch. Batch documentation is available on request.
Previous batch CoAs are archived in the CoA library. For batch-specific CoA requests prior to purchase, contact support@veloxpeps.com.
Delivery & payment
Buying Kisspeptin-10 in the UK
Kisspeptin-10 is sold by Velox Peptides (CRP Labs Ltd, UK company no. NI738125) and dispatched from the UK. Choose a vial size, pay on one page, and your order is dispatched the next working day.
- Delivery: Royal Mail Tracked 24 (1–2 working days, £5.99, free over £100) or Tracked 48 (2–3 working days, £3.80). See shipping.
- Payment: Pay by Bank through FCA-authorised open banking, or bank transfer. No card details needed.
- Testing: See the batch testing details above and past reports in the CoA library.
- Research use only: Supplied as a research reagent for in vitro use. Not for human or veterinary consumption. See our Research Use Policy.
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Compliance notice
For in vitro research use only. Kisspeptin-10 is supplied solely as a research reagent for qualified professionals conducting in vitro or animal-model studies. It is not a medicinal product within the meaning of the Human Medicines Regulations 2012. It has not been evaluated by the MHRA or FDA. It is not intended for human or veterinary consumption, diagnosis, treatment, cure, or prevention of any condition. Any use outside lawful scientific research is outside the scope of sale.
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