Growth factor
IGF-1 LR3 Long R3 IGF-1 · IGF-1 Analogue
Growth factor
IGF-1 LR3 research overview
- CAS Number
- 946870-92-4
- Molecular Formula
- C₄₀₀H₆₂₅N₁₁₁O₁₁₅S₉
- HPLC Purity
- ≥99% (batch-verified)
- Form
- Lyophilised powder
- Storage
- 2–8°C, desiccated, protected from light
- Classification
- Research reagent - in vitro use only
IGF-1 LR3 (Long R3 IGF-1) is an 83-amino-acid analogue of human insulin-like growth factor 1. It differs from the native 70-residue protein by an arginine substitution at position 3 and a 13-residue extension at the N-terminus, and it is one of the most widely used growth factor reagents in cell culture.
The two modifications sharply reduce binding to the IGF-binding proteins (IGFBPs) that normally sequester IGF-1 in serum and conditioned media, while binding to the type 1 IGF receptor (IGF-1R) is retained. As a result, more of the analogue remains free to reach the receptor in experimental systems than is the case for native IGF-1.
In cell-based research, IGF-1 LR3 is used as a media supplement and as a tool for studying IGF-1R signalling through the PI3K-Akt and MAPK pathways. It is widely used in serum-free culture of mammalian cell lines, including in recombinant protein production, where it is used in place of insulin to support cell proliferation and viability.
IGF-1 LR3 is supplied in a smaller quantity than most peptides in the catalogue because it is used at very low concentrations in culture. Velox Peptides supplies IGF-1 LR3 at ≥99% HPLC-verified purity as a 1mg lyophilised research reagent. Not for human or veterinary consumption.
Summary paraphrased from the peer-reviewed preclinical literature. For in vitro research use only. For source citations, email support@veloxpeps.com.
IGF-1 LR3 Research Hub
Technical data
Compound specifications
| Common name | IGF-1 LR3 (Long R3 IGF-1, LR3-IGF-1) |
|---|---|
| Full name | Long Arg3 insulin-like growth factor 1 (83 residues) |
| CAS number | 946870-92-4 |
| Molecular formula | C₄₀₀H₆₂₅N₁₁₁O₁₁₅S₉ |
| Molecular weight | 9117.6 g/mol |
| Sequence | 83-residue IGF-1 analogue: Arg substituted for Glu at position 3, with a 13-residue N-terminal extension |
| HPLC purity | ≥99% (batch-verified) |
| Appearance | White to off-white lyophilised powder |
| Solubility | Bacteriostatic water, sterile saline |
| Storage (lyophilised) | 2–8°C, protected from light |
| Storage (reconstituted) | 2–8°C, up to 28 days |
| Supplied as | 1mg |
Purity & documentation
Batch testing and certificate of analysis
Every batch of IGF-1 LR3 is third-party HPLC-tested prior to dispatch. Batch documentation is available on request.
Previous batch CoAs are archived in the CoA library. For batch-specific CoA requests prior to purchase, contact support@veloxpeps.com.
Delivery & payment
Buying IGF-1 LR3 in the UK
IGF-1 LR3 is sold by Velox Peptides (CRP Labs Ltd, UK company no. NI738125) and dispatched from the UK. Choose a vial size, pay on one page, and your order is dispatched the next working day.
- Delivery: Royal Mail Tracked 24 (1–2 working days, £5.99, free over £100) or Tracked 48 (2–3 working days, £3.80). See shipping.
- Payment: Pay by Bank through FCA-authorised open banking, or bank transfer. No card details needed.
- Testing: See the batch testing details above and past reports in the CoA library.
- Research use only: Supplied as a research reagent for in vitro use. Not for human or veterinary consumption. See our Research Use Policy.
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Compliance notice
For in vitro research use only. IGF-1 LR3 is supplied solely as a research reagent for qualified professionals conducting in vitro or animal-model studies. It is not a medicinal product within the meaning of the Human Medicines Regulations 2012. It has not been evaluated by the MHRA or FDA. It is not intended for human or veterinary consumption, diagnosis, treatment, cure, or prevention of any condition. Any use outside lawful scientific research is outside the scope of sale.
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