Immune
Thymosin Alpha-1 Tα1 · Thymic Peptide
Immune
Thymosin Alpha-1 research overview
- CAS Number
- 62304-98-7
- Molecular Formula
- C₁₂₉H₂₁₅N₃₃O₅₅
- HPLC Purity
- ≥99% (batch-verified)
- Form
- Lyophilised powder
- Storage
- 2–8°C, desiccated, protected from light
- Classification
- Research reagent - in vitro use only
Thymosin Alpha-1 (Tα1) is a 28-amino-acid, N-terminally acetylated peptide first isolated from thymosin fraction 5, a preparation of calf thymus. The synthetic form is identical in sequence to the natural human peptide and is a long-established reference compound in immunology research.
Thymosin Alpha-1 was isolated and sequenced by Allan Goldstein and colleagues in the 1970s. In the body it is produced by cleavage of a larger precursor, prothymosin alpha. The peptide is highly acidic, with a large proportion of glutamic and aspartic acid residues, and is largely unstructured in aqueous solution.
In cell-based research, Thymosin Alpha-1 is studied for its effects on dendritic cells and T-cell subsets, and for signalling through Toll-like receptors, particularly TLR2 and TLR9, and the downstream MyD88 pathway. In vitro work examines cytokine expression, antigen-presenting cell maturation markers and T-cell differentiation in culture.
Thymosin Alpha-1 is distinct from Thymosin Beta-4 and its fragment TB-500, which are actin-binding peptides studied in tissue-repair models. Velox Peptides supplies Thymosin Alpha-1 at ≥99% HPLC-verified purity as a 5mg lyophilised research reagent. Not for human or veterinary consumption.
Summary paraphrased from the peer-reviewed preclinical literature. For in vitro research use only. For source citations, email support@veloxpeps.com.
Thymosin Alpha-1 Research Hub
Technical data
Compound specifications
| Common name | Thymosin Alpha-1 (Tα1, Thymalfasin) |
|---|---|
| Full name | N-acetyl thymosin α1 (28 residues) |
| CAS number | 62304-98-7 |
| Molecular formula | C₁₂₉H₂₁₅N₃₃O₅₅ |
| Molecular weight | 3108.3 g/mol |
| Sequence | Ac-Ser-Asp-Ala-Ala-Val-Asp-Thr-Ser-Ser-Glu-Ile-Thr-Thr-Lys-Asp-Leu-Lys-Glu-Lys-Lys-Glu-Val-Val-Glu-Glu-Ala-Glu-Asn-OH |
| HPLC purity | ≥99% (batch-verified) |
| Appearance | White to off-white lyophilised powder |
| Solubility | Bacteriostatic water, sterile saline |
| Storage (lyophilised) | 2–8°C, protected from light |
| Storage (reconstituted) | 2–8°C, up to 28 days |
| Supplied as | 5mg |
Purity & documentation
Batch testing and certificate of analysis
Every batch of Thymosin Alpha-1 is third-party HPLC-tested prior to dispatch. Batch documentation is available on request.
Previous batch CoAs are archived in the CoA library. For batch-specific CoA requests prior to purchase, contact support@veloxpeps.com.
Delivery & payment
Buying Thymosin Alpha-1 in the UK
Thymosin Alpha-1 is sold by Velox Peptides (CRP Labs Ltd, UK company no. NI738125) and dispatched from the UK. Choose a vial size, pay on one page, and your order is dispatched the next working day.
- Delivery: Royal Mail Tracked 24 (1–2 working days, £5.99, free over £100) or Tracked 48 (2–3 working days, £3.80). See shipping.
- Payment: Pay by Bank through FCA-authorised open banking, or bank transfer. No card details needed.
- Testing: See the batch testing details above and past reports in the CoA library.
- Research use only: Supplied as a research reagent for in vitro use. Not for human or veterinary consumption. See our Research Use Policy.
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Compliance notice
For in vitro research use only. Thymosin Alpha-1 is supplied solely as a research reagent for qualified professionals conducting in vitro or animal-model studies. It is not a medicinal product within the meaning of the Human Medicines Regulations 2012. It has not been evaluated by the MHRA or FDA. It is not intended for human or veterinary consumption, diagnosis, treatment, cure, or prevention of any condition. Any use outside lawful scientific research is outside the scope of sale.
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