Mitochondrial
SS-31 Elamipretide · Mitochondrial Peptide
Mitochondrial
SS-31 research overview
- CAS Number
- 736992-21-5
- Molecular Formula
- C₃₂H₄₉N₉O₅
- HPLC Purity
- ≥99% (batch-verified)
- Form
- Lyophilised powder
- Storage
- 2–8°C, desiccated, protected from light
- Classification
- Research reagent - in vitro use only
SS-31 (elamipretide) is a synthetic aromatic-cationic tetrapeptide with the sequence D-Arg-Dmt-Lys-Phe-NH₂. It is one of the Szeto-Schiller peptides, a family of cell-permeable compounds that concentrate at the inner mitochondrial membrane, and it is widely used as a tool in mitochondrial research.
The Szeto-Schiller (SS) peptides were described by Hazel Szeto and Peter Schiller. They alternate aromatic and basic residues, a motif that allows uptake into cells and accumulation in mitochondria. SS-31 contains 2′,6′-dimethyltyrosine (Dmt), which contributes to its radical-scavenging behaviour in chemical assays.
In cell-based and isolated-mitochondria research, SS-31 is studied for its selective binding to cardiolipin, a phospholipid found almost exclusively in the inner mitochondrial membrane. Published work examines how this interaction affects cristae structure, electron transport chain efficiency, cytochrome c peroxidase activity and the generation of reactive oxygen species.
SS-31 is commonly used alongside other compounds in mitochondrial and redox research, including MOTS-c, NAD+ and Glutathione. Velox Peptides supplies SS-31 at ≥99% HPLC-verified purity as 10mg and 50mg lyophilised research reagents. Not for human or veterinary consumption.
Summary paraphrased from the peer-reviewed preclinical literature. For in vitro research use only. For source citations, email support@veloxpeps.com.
SS-31 Research Hub
Technical data
Compound specifications
| Common name | SS-31 (Elamipretide, MTP-131) |
|---|---|
| Full name | Elamipretide (D-Arg-Dmt-Lys-Phe-NH₂) |
| CAS number | 736992-21-5 |
| Molecular formula | C₃₂H₄₉N₉O₅ |
| Molecular weight | 639.8 g/mol |
| Sequence | D-Arg-Dmt-Lys-Phe-NH2 (Dmt = 2′,6′-dimethyltyrosine) |
| HPLC purity | ≥99% (batch-verified) |
| Appearance | White to off-white lyophilised powder |
| Solubility | Bacteriostatic water, sterile saline |
| Storage (lyophilised) | 2–8°C, protected from light |
| Storage (reconstituted) | 2–8°C, up to 28 days |
| Supplied as | 10mg, 50mg |
Purity & documentation
Batch testing and certificate of analysis
Every batch of SS-31 is third-party HPLC-tested prior to dispatch. Batch documentation is available on request.
Previous batch CoAs are archived in the CoA library. For batch-specific CoA requests prior to purchase, contact support@veloxpeps.com.
Delivery & payment
Buying SS-31 in the UK
SS-31 is sold by Velox Peptides (CRP Labs Ltd, UK company no. NI738125) and dispatched from the UK. Choose a vial size, pay on one page, and your order is dispatched the next working day.
- Delivery: Royal Mail Tracked 24 (1–2 working days, £5.99, free over £100) or Tracked 48 (2–3 working days, £3.80). See shipping.
- Payment: Pay by Bank through FCA-authorised open banking, or bank transfer. No card details needed.
- Testing: See the batch testing details above and past reports in the CoA library.
- Research use only: Supplied as a research reagent for in vitro use. Not for human or veterinary consumption. See our Research Use Policy.
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Compliance notice
For in vitro research use only. SS-31 is supplied solely as a research reagent for qualified professionals conducting in vitro or animal-model studies. It is not a medicinal product within the meaning of the Human Medicines Regulations 2012. It has not been evaluated by the MHRA or FDA. It is not intended for human or veterinary consumption, diagnosis, treatment, cure, or prevention of any condition. Any use outside lawful scientific research is outside the scope of sale.
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