Amylin analogue
Cagrilintide Long-Acting Amylin Analogue
Amylin analogue
Cagrilintide research overview
- CAS Number
- 1415456-99-3
- Molecular Formula
- C₁₉₄H₃₁₂N₅₄O₅₉S₂
- HPLC Purity
- ≥99% (batch-verified)
- Form
- Lyophilised powder
- Storage
- 2–8°C, desiccated, protected from light
- Classification
- Research reagent - in vitro use only
Cagrilintide is a synthetic, lipidated analogue of amylin, a 37-amino-acid hormone co-secreted with insulin by pancreatic beta cells. It is used in preclinical research as a stable, long-acting agonist of the amylin receptor family.
Native human amylin is difficult to work with because it readily aggregates into amyloid fibrils. Cagrilintide incorporates amino-acid substitutions that reduce fibril formation, together with a C20 fatty diacid side chain that promotes reversible binding to albumin. A disulfide bridge between the cysteine residues at positions 2 and 7 and a C-terminal amide are retained from the native hormone.
In cell-based research, Cagrilintide is studied as a non-selective agonist of the amylin receptors (AMY1, AMY2 and AMY3), which are formed when the calcitonin receptor pairs with receptor activity-modifying proteins (RAMPs), and of the calcitonin receptor itself. Functional assays typically measure cAMP accumulation in cell lines expressing defined receptor and RAMP combinations.
Rodent studies have used Cagrilintide to investigate amylin-receptor signalling in the area postrema and hypothalamus and its role in energy homeostasis, and it is frequently studied in combination with incretin-receptor agonists such as Retatrutide. Velox Peptides supplies Cagrilintide at ≥99% HPLC-verified purity as a 5mg lyophilised research reagent. Not for human or veterinary consumption.
Summary paraphrased from the peer-reviewed preclinical literature. For in vitro research use only. For source citations, email support@veloxpeps.com.
Cagrilintide Research Hub
Technical data
Compound specifications
| Common name | Cagrilintide (AM833, NN9838) |
|---|---|
| Full name | Acylated long-acting amylin analogue (37 residues) |
| CAS number | 1415456-99-3 |
| Molecular formula | C₁₉₄H₃₁₂N₅₄O₅₉S₂ |
| Molecular weight | 4409.0 g/mol |
| Sequence | 37-residue acylated amylin analogue with a C20 fatty diacid side chain and a Cys2–Cys7 disulfide |
| HPLC purity | ≥99% (batch-verified) |
| Appearance | White to off-white lyophilised powder |
| Solubility | Bacteriostatic water, sterile saline |
| Storage (lyophilised) | 2–8°C, protected from light |
| Storage (reconstituted) | 2–8°C, up to 28 days |
| Supplied as | 5mg |
Purity & documentation
Batch testing and certificate of analysis
Every batch of Cagrilintide is third-party HPLC-tested prior to dispatch. Batch documentation is available on request.
Previous batch CoAs are archived in the CoA library. For batch-specific CoA requests prior to purchase, contact support@veloxpeps.com.
Delivery & payment
Buying Cagrilintide in the UK
Cagrilintide is sold by Velox Peptides (CRP Labs Ltd, UK company no. NI738125) and dispatched from the UK. Choose a vial size, pay on one page, and your order is dispatched the next working day.
- Delivery: Royal Mail Tracked 24 (1–2 working days, £5.99, free over £100) or Tracked 48 (2–3 working days, £3.80). See shipping.
- Payment: Pay by Bank through FCA-authorised open banking, or bank transfer. No card details needed.
- Testing: See the batch testing details above and past reports in the CoA library.
- Research use only: Supplied as a research reagent for in vitro use. Not for human or veterinary consumption. See our Research Use Policy.
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Compliance notice
For in vitro research use only. Cagrilintide is supplied solely as a research reagent for qualified professionals conducting in vitro or animal-model studies. It is not a medicinal product within the meaning of the Human Medicines Regulations 2012. It has not been evaluated by the MHRA or FDA. It is not intended for human or veterinary consumption, diagnosis, treatment, cure, or prevention of any condition. Any use outside lawful scientific research is outside the scope of sale.
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