Tissue-protective
ARA-290 Cibinetide · EPO-Derived Peptide
Tissue-protective
ARA-290 research overview
- CAS Number
- 1208243-50-8
- Molecular Formula
- C₅₁H₈₄N₁₆O₂₁
- HPLC Purity
- ≥99% (batch-verified)
- Form
- Lyophilised powder
- Storage
- 2–8°C, desiccated, protected from light
- Classification
- Research reagent - in vitro use only
ARA-290 (cibinetide) is a synthetic 11-amino-acid peptide modelled on the three-dimensional structure of the helix B surface of erythropoietin (EPO). It was designed to reproduce the tissue-protective signalling of EPO in experimental systems without its effect on red blood cell production.
Erythropoietin signals through two distinct receptors: the classical EPO receptor homodimer, which drives erythropoiesis, and a heteromeric receptor formed by the EPO receptor and the beta common receptor (CD131), referred to as the innate repair receptor. ARA-290, also known as pyroglutamate helix B surface peptide (pHBSP), was developed by Michael Brines, Anthony Cerami and colleagues to engage only the second of these.
In cell-based research, ARA-290 is used to study innate repair receptor signalling, including JAK2 activation and downstream anti-inflammatory and cytoprotective pathways, in endothelial, neuronal and immune-cell models. Published work examines cytokine expression and cell survival under experimental stress conditions.
Rodent studies have examined ARA-290 in models of nerve-fibre injury and tissue inflammation. It is studied alongside other tissue-model compounds in the catalogue such as BPC-157, TB-500 and KPV. Velox Peptides supplies ARA-290 at ≥99% HPLC-verified purity as a 10mg lyophilised research reagent. Not for human or veterinary consumption.
Summary paraphrased from the peer-reviewed preclinical literature. For in vitro research use only. For source citations, email support@veloxpeps.com.
ARA-290 Research Hub
Technical data
Compound specifications
| Common name | ARA-290 (Cibinetide, pHBSP) |
|---|---|
| Full name | Cibinetide (pyroglutamate helix B surface peptide) |
| CAS number | 1208243-50-8 |
| Molecular formula | C₅₁H₈₄N₁₆O₂₁ |
| Molecular weight | 1257.3 g/mol |
| Sequence | pGlu-Glu-Gln-Leu-Glu-Arg-Ala-Leu-Asn-Ser-Ser |
| HPLC purity | ≥99% (batch-verified) |
| Appearance | White to off-white lyophilised powder |
| Solubility | Bacteriostatic water, sterile saline |
| Storage (lyophilised) | 2–8°C, protected from light |
| Storage (reconstituted) | 2–8°C, up to 28 days |
| Supplied as | 10mg |
Purity & documentation
Batch testing and certificate of analysis
Every batch of ARA-290 is third-party HPLC-tested prior to dispatch. Batch documentation is available on request.
Previous batch CoAs are archived in the CoA library. For batch-specific CoA requests prior to purchase, contact support@veloxpeps.com.
Delivery & payment
Buying ARA-290 in the UK
ARA-290 is sold by Velox Peptides (CRP Labs Ltd, UK company no. NI738125) and dispatched from the UK. Choose a vial size, pay on one page, and your order is dispatched the next working day.
- Delivery: Royal Mail Tracked 24 (1–2 working days, £5.99, free over £100) or Tracked 48 (2–3 working days, £3.80). See shipping.
- Payment: Pay by Bank through FCA-authorised open banking, or bank transfer. No card details needed.
- Testing: See the batch testing details above and past reports in the CoA library.
- Research use only: Supplied as a research reagent for in vitro use. Not for human or veterinary consumption. See our Research Use Policy.
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Compliance notice
For in vitro research use only. ARA-290 is supplied solely as a research reagent for qualified professionals conducting in vitro or animal-model studies. It is not a medicinal product within the meaning of the Human Medicines Regulations 2012. It has not been evaluated by the MHRA or FDA. It is not intended for human or veterinary consumption, diagnosis, treatment, cure, or prevention of any condition. Any use outside lawful scientific research is outside the scope of sale.
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