Metabolic
AOD-9604 hGH Fragment Analogue (177-191)
Metabolic
AOD-9604 research overview
- CAS Number
- 221231-10-3
- Molecular Formula
- C₇₈H₁₂₃N₂₃O₂₃S₂
- HPLC Purity
- ≥99% (batch-verified)
- Form
- Lyophilised powder
- Storage
- 2–8°C, desiccated, protected from light
- Classification
- Research reagent - in vitro use only
AOD-9604 is a synthetic 16-amino-acid peptide based on the C-terminal region (residues 177-191) of human growth hormone, with an additional tyrosine at the N-terminus. It is used in preclinical research to study the lipid-metabolism properties of this region of the hormone separately from the full-length protein.
AOD-9604 was developed at Monash University from earlier work showing that the C-terminal fragment of growth hormone retained activity on fat metabolism in experimental systems. The peptide contains a disulfide bridge between its two cysteine residues, forming a constrained loop, and the added tyrosine was introduced to stabilise the molecule.
In cell-based research, AOD-9604 has been studied in adipocyte models for effects on lipolysis and lipogenesis, and rodent studies have examined its relationship to beta-3 adrenergic receptor expression. A consistent finding in the published literature is that it does not bind the growth hormone receptor or raise IGF-1 in the models tested, which distinguishes it from full-length growth hormone.
AOD-9604 is closely related to hGH Fragment 176-191 and is used by researchers working on metabolic pathways alongside compounds such as MOTS-c and Retatrutide. Velox Peptides supplies AOD-9604 at ≥99% HPLC-verified purity as a 5mg lyophilised research reagent. Not for human or veterinary consumption.
Summary paraphrased from the peer-reviewed preclinical literature. For in vitro research use only. For source citations, email support@veloxpeps.com.
AOD-9604 Research Hub
Technical data
Compound specifications
| Common name | AOD-9604 (AOD9604, Tyr-hGH 177-191) |
|---|---|
| Full name | Tyr-hGH(177-191), disulfide-bridged |
| CAS number | 221231-10-3 |
| Molecular formula | C₇₈H₁₂₃N₂₃O₂₃S₂ |
| Molecular weight | 1815.1 g/mol |
| Sequence | Tyr-Leu-Arg-Ile-Val-Gln-Cys-Arg-Ser-Val-Glu-Gly-Ser-Cys-Gly-Phe (Cys7–Cys14 disulfide) |
| HPLC purity | ≥99% (batch-verified) |
| Appearance | White to off-white lyophilised powder |
| Solubility | Bacteriostatic water, sterile saline |
| Storage (lyophilised) | 2–8°C, protected from light |
| Storage (reconstituted) | 2–8°C, up to 28 days |
| Supplied as | 5mg |
Purity & documentation
Batch testing and certificate of analysis
Every batch of AOD-9604 is third-party HPLC-tested prior to dispatch. Batch documentation is available on request.
Previous batch CoAs are archived in the CoA library. For batch-specific CoA requests prior to purchase, contact support@veloxpeps.com.
Delivery & payment
Buying AOD-9604 in the UK
AOD-9604 is sold by Velox Peptides (CRP Labs Ltd, UK company no. NI738125) and dispatched from the UK. Choose a vial size, pay on one page, and your order is dispatched the next working day.
- Delivery: Royal Mail Tracked 24 (1–2 working days, £5.99, free over £100) or Tracked 48 (2–3 working days, £3.80). See shipping.
- Payment: Pay by Bank through FCA-authorised open banking, or bank transfer. No card details needed.
- Testing: See the batch testing details above and past reports in the CoA library.
- Research use only: Supplied as a research reagent for in vitro use. Not for human or veterinary consumption. See our Research Use Policy.
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Compliance notice
For in vitro research use only. AOD-9604 is supplied solely as a research reagent for qualified professionals conducting in vitro or animal-model studies. It is not a medicinal product within the meaning of the Human Medicines Regulations 2012. It has not been evaluated by the MHRA or FDA. It is not intended for human or veterinary consumption, diagnosis, treatment, cure, or prevention of any condition. Any use outside lawful scientific research is outside the scope of sale.
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