DSIP DSIP PRODUCT IMAGE
HPLC VERIFIED CoA SUPPLIED ≥99% PURITY
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DSIP Delta Sleep-Inducing Peptide

For in vitro research use only. DSIP is not for human or veterinary consumption, diagnosis, treatment, or prevention of any condition.

DSIP is a short neuropeptide (a type of small protein used for signalling between brain cells) made up of just 9 amino acids. It was first isolated from rabbit blood during deep sleep. Animal studies have investigated how it interacts with the structure of sleep - particularly the deep, slow-wave stages - and how it affects the body's stress-response systems.

CAS Number
62568-57-4
Molecular Formula
C₃₅H₄₈N₁₀O₁₅
HPLC Purity
≥99% (batch-verified)
Form
Lyophilised powder
Storage
2–8°C, desiccated, protected from light
Classification
Research reagent - in vitro use only
≥99%
HPLC purity
3rd-Party Tested
Independent lab
CoA Every Order
Batch-specific
Tracked 24
Royal Mail UK
Pay by Bank
No card stored

Research overview

DSIP (Delta Sleep-Inducing Peptide) is a nonapeptide with the sequence Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu. It was first isolated from the cerebral venous blood of rabbits in 1977 by Schoenenberger and Monnier, following electrical stimulation of the thalamus during sleep induction experiments — giving rise to its name. Unlike most synthetic peptide research compounds, DSIP is an endogenous neuropeptide identified in the hypothalamus, limbic system, pituitary, and peripheral tissues of mammals, though it is supplied here as a synthesised research reagent for controlled experimental conditions.

The primary area of research interest for DSIP has been sleep regulation and neuroendocrine modulation. Early rodent studies reported that peripheral and central administration of DSIP modified slow-wave and delta sleep patterns, though subsequent research has produced variable results and the precise mechanism by which DSIP interacts with sleep architecture remains an active area of investigation. Separately, research has examined DSIP’s role in stress axis modulation — specifically its effects on corticotropin-releasing hormone (CRH) and ACTH secretion — suggesting a potential interface between the sleep regulatory system and the hypothalamic-pituitary-adrenal (HPA) axis.

DSIP has also been studied for antioxidant properties and neuroprotective potential in cell culture models, and for its interaction with opioid peptide systems and basal ganglia function. Its relatively small, stable nonapeptide structure makes it a practical tool for studying receptor binding kinetics and neuroendocrine signalling in vitro. Velox Peptides supplies DSIP at ≥99% HPLC-verified purity as a lyophilised research reagent for in vitro use by qualified researchers. Not for human or veterinary consumption.

Summary paraphrased from the peer-reviewed preclinical literature. For in vitro research use only. For source citations, email support@veloxpeps.com.

Compound specifications

Common nameDSIP
Full nameDelta Sleep-Inducing Peptide
CAS number62568-57-4
Molecular formulaC₃₅H₄₈N₁₀O₁₅
Molecular weight848.9 g/mol
SequenceWAGGDASGE
HPLC purity≥99% (batch-verified)
AppearanceWhite to off-white lyophilised powder
SolubilityBacteriostatic water, sterile saline
Storage (lyophilised)2–8°C, protected from light
Storage (reconstituted)2–8°C, up to 28 days
Supplied as5mg, 10mg

Batch testing and certificate of analysis

Every batch of DSIP is third-party HPLC-tested prior to dispatch. Batch documentation is available on request.

Previous batch CoAs are archived in the CoA library. For batch-specific CoA requests prior to purchase, contact support@veloxpeps.com.

Frequently Asked Research-Use Questions

What purity is Velox Peptides DSIP?
DSIP is supplied at ≥99% HPLC-verified purity. Batch documentation is available on request.
How is DSIP supplied and reconstituted for research use?
DSIP is supplied as a lyophilised powder in sterile single-use vials. For in vitro research use, reconstitution is performed with bacteriostatic water. See the reconstitution calculator for volume calculations based on required concentration.
What is DSIP used for in preclinical research?
DSIP is studied in the peer-reviewed literature across the pathways described in the research overview above. Velox Peptides supplies DSIP strictly as a research reagent for in vitro use by qualified researchers. It is not a medicinal product and is not for human or veterinary consumption.
What is the CAS number for DSIP?
The CAS registry number for DSIP is 62568-57-4.
Is DSIP legal to buy in the UK?
Yes. Research peptides including DSIP are lawful to purchase in the United Kingdom strictly for legitimate in vitro scientific research purposes. They are not controlled substances under UK law and are not subject to prescription requirements when purchased for research use. Velox Peptides supplies DSIP solely as a research reagent to qualified researchers. Buyers are responsible for ensuring all use complies with applicable law and with Velox Peptides’ Research Use Policy.
Where and when was DSIP first isolated, and what does its name refer to?
DSIP (Delta Sleep-Inducing Peptide) was first isolated from the cerebral venous blood of rabbits in 1977 by researchers Schoenenberger and Monnier at the University of Basel, following experiments in which the thalamus was electrically stimulated to induce sleep. The name refers to its observed association with delta (slow-wave) sleep in initial animal studies. DSIP has the amino acid sequence Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu (nine residues, making it a nonapeptide) and CAS number 62568-57-4. It is found endogenously in several mammalian tissues including the hypothalamus and pituitary.
How quickly is my order dispatched and delivered?
Orders placed before 2pm on a working day are dispatched the same day via Royal Mail Tracked 24, typically arriving in 1–2 working days, with tracking emailed on dispatch. UK shipping is free over £100, and EU shipping is available.
How do I pay, and is it secure?
We accept Pay by Bank - an instant, secure open-banking payment via Fena, where you authorise the payment in your own banking app and no card details are stored on our site. Manual UK bank transfer is available as a fallback. Orders are dispatched within 24 hours of cleared payment.
Does my order include a certificate of analysis?
Yes. Every order includes a batch-specific Certificate of Analysis documenting third-party HPLC purity and mass-spectrometry identity confirmation, emailed with your order confirmation. Previous batch CoAs are archived in our CoA library.

Compliance notice

For in vitro research use only. DSIP is supplied solely as a research reagent for qualified professionals conducting in vitro or animal-model studies. It is not a medicinal product within the meaning of the Human Medicines Regulations 2012. It has not been evaluated by the MHRA or FDA. It is not intended for human or veterinary consumption, diagnosis, treatment, cure, or prevention of any condition. Any use outside lawful scientific research is outside the scope of sale.

Compliance statement. Velox Peptides supplies research reagents for in vitro use by qualified researchers. Every compound is sold strictly as a research reagent. No product is a medicinal product within the meaning of the Human Medicines Regulations 2012. No product has been evaluated by the MHRA or FDA. No product is intended for human or veterinary consumption, diagnosis, treatment, cure, or prevention of any condition. Any use outside lawful scientific research is outside the scope of sale. See our Research Use Policy and MHRA Statement.