NEUROPEPTIDE RESEARCH

DSIP: Delta Sleep-Inducing Peptide Research

Velox Peptides Research Team·Published May 2026·5 min read
CAS Number
62568-57-4
Peptide Length
9 amino acids
Origin
Endogenous neuropeptide
HPLC Purity
≥98.7% (batch-verified)
For in vitro research use only. DSIP is supplied solely as a research reagent for in vitro use and is not for human or veterinary consumption.

What is DSIP?

DSIP (Delta Sleep-Inducing Peptide) is a naturally occurring nonapeptide (nine amino acids) first isolated from the brain in studies of sleep regulation. Its name comes from its original association with the induction of delta-wave (deep, slow-wave) sleep in early animal experiments.

DSIP is an endogenous peptide — one the body produces naturally — which makes it a research tool for studying neuropeptide involvement in sleep architecture and stress physiology.

Sleep modulation and stress-response research

Delta-wave sleep. Preclinical research has examined DSIP’s association with changes in sleep architecture, particularly slow-wave (delta) sleep, in rodent models. The precise receptor mechanism remains incompletely characterised, which is itself an active area of study.

Stress and neuroendocrine signalling. Beyond sleep, DSIP has been studied for its association with attenuation of stress responses and modulation of neuroendocrine and antioxidant pathways in animal models, making it a multi-pathway research reagent.

Research context

DSIP sits within the neuropeptide research category alongside Selank and Semax, which are studied for distinct but related neuropeptide-signalling pathways.

Velox Peptides supply information

Velox Peptides supplies DSIP as a lyophilised powder at ≥98.7% HPLC-verified purity with a batch certificate of analysis available on request. For reconstitution, see the reconstitution calculator. Supplied strictly as a research reagent for in vitro use.

References & further reading

  1. Graf MV, Kastin AJ. “Delta-sleep-inducing peptide (DSIP): a review.” Neuroscience & Biobehavioral Reviews, 1984.
  2. Kovalzon VM, Strekalova TV. “Delta sleep-inducing peptide (DSIP): a still unresolved riddle.” Journal of Neurochemistry, review literature.

Summaries are paraphrased from the peer-reviewed literature. For full source citations, email veloxpeps@gmail.com.

Frequently asked questions

What is DSIP?
DSIP (Delta Sleep-Inducing Peptide) is an endogenous nonapeptide studied for its association with delta-wave sleep modulation. Velox Peptides supplies it as a research reagent for in vitro use only.
What is DSIP studied for?
In preclinical models DSIP is studied for its association with sleep architecture (especially slow-wave sleep) and with stress-response attenuation.
What purity is Velox Peptides DSIP?
DSIP is HPLC-verified at a minimum of 98.7% purity, with batch documentation available on request.
Is DSIP legal to buy in the UK?
Yes — for in vitro research purposes. Velox Peptides supplies it solely as a research reagent, not for human or veterinary use.
Compliance statement. Velox Peptides supplies research reagents for in vitro use by qualified researchers. Every compound is sold strictly as a research reagent. No product is a medicinal product within the meaning of the Human Medicines Regulations 2012. No product has been evaluated by the MHRA or FDA. No product is intended for human or veterinary consumption, diagnosis, treatment, cure, or prevention of any condition. Any use outside lawful scientific research is outside the scope of sale. See our Research Use Policy and MHRA Statement.

All research summaries on this page are derived from publicly available peer-reviewed literature. Velox Peptides makes no therapeutic claims. For research use only.