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CJC-1295 (no DAC) vs Ipamorelin — comparison summary

This page compares CJC-1295 (no DAC) and Ipamorelin across mechanism of action, receptor targets, molecular weight, solubility and research focus, for in vitro research use only.

CJC-1295 (no DAC)

A GHRH analogue studied for pulsatile growth-hormone release.

Mechanism
A modified fragment of growth-hormone-releasing hormone (GHRH 1-29) that stimulates the pituitary to release growth hormone in preclinical models.
Receptor targets
GHRH receptor (GHRH-R) on pituitary somatotrophs.
Molecular weight
3367.9 g/mol
Solubility
Water-soluble
Research focus
Frequently studied alongside ghrelin-receptor agonists (e.g. Ipamorelin) for synergistic GH release.

Ipamorelin

One of the most selective growth-hormone secretagogues studied.

Mechanism
A pentapeptide that selectively activates the ghrelin receptor to prompt GH release with little effect on cortisol or prolactin in preclinical models.
Receptor targets
Ghrelin receptor (GHS-R1a).
Molecular weight
711.9 g/mol
Solubility
Water-soluble
Research focus
Studied as a clean tool for isolating GH-secretagogue signalling; often paired with CJC-1295.
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